https://www.igjps.com/index.php/IGJPS <p>IGJPS is an international journal online. It is interdisciplinary and aims to bring together different approaches for a diverse readership all over the world in pharmaceutical sciences. This Journal publishes original research work that contributes significantly to further the scientific knowledge in pharmacy and pharmaceutical sciences (Pharmaceutical Technology, Pharmacognosy, Natural Product Research, Pharmaceutics, Novel Drug Delivery, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest). The Journal publishes original research work either as a Full Research Paper or as a Short Communication. Review Articles on a current topic in the said fields are also considered for publication by the Journal.</p> Caproslaxy Media (Formerly, iGlobal Research and Publishing Foundation) en-US Indo Global Journal of Pharmaceutical Sciences 2249-1023 https://www.igjps.com/index.php/IGJPS/article/view/412 <p>This study explored the anti-diarrheal properties of <em>Gouania longipetala</em> crude extract in a rat model, aiming to provide scientific validation for its traditional use as a remedy for diarrhea. The extract was evaluated using different doses (200, 400, 600 and 800 mg/kg body weight) orally for anti-diarrhea activity in albino rats induced for diarrhea with castor oil, charcoal meal transit time leading to enteropooling. The activities of the crude extract at different doses of up to 800 mg/kg body weight were compared with that of the standard drug, loperamide (0.5 mg/kg). Data were analyzed using, statistical package for the Social Sciences, Version 18.0. In the <em>in vivo </em>anti-diarrhea studies, the crude extract at all doses used showed significant (P&lt;0.05) antidiarrheal activity, evidenced by delay in the onset of diarrhea of up to 56.00±4.36 mins, compared with the control 58.60±3.65. The extract also significantly decreased the distance travelled by the charcoal meal in a dose-dependent manner, with the highest activity of 59.4±2.70^b observed for 800 mg/kg of the extract. This favorably compared with that of loperamide with 50.2±1.64^a decrease. These results represent 33.17±1.88^e % and 33.17±2.41^f % inhibitions respectively (P&gt;0.05). The enteropooling study showed reduction in the intraluminal fluid accumulation in all groups in a dose-dependent manner, with highest reduction observed in the group treated with 800 mg/kg b.w. of the extract (from 13.30±1.69^dg to 5.90±1.49^a,breduction), compared with loperamide (5.18±1.54^a reduction). The findings of this study demonstrate that <em>Gouania longipetala</em> exhibits significant anti-diarrheal activity (P&lt;0.05), validating its traditional use and suggesting its potential as a natural source for the development of novel anti-diarrheal agents.</p> Kenneth C. Nwachukwu Michael P. Okoh Copyright (c) 2026 Indo Global Journal of Pharmaceutical Sciences 2026-04-29 2026-04-29 16 1 9 10.35652/IGJPS.2026.16001